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KMID : 0960920030020010058
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Dementia and Neurocognitive Disorders
2003 Volume.2 No. 1 p.58 ~ p.64
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A Case of Semantic Dementia : Serial Follow-up Study of Neuropsychological and Neuroimaging Findings
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Park Kyung-Won
Kim Wook-Joo
Jeon Jin-Min
Kang Do-Young
Kim Jae-Woo
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Abstract
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Semantic dementia (SD) is a very rare, distinct form of dementia which is characterized by impairment of naming and comprehension, prosopagnosia, visual agnosia for objects and relative preservation of other aspects of cognition, such as episodic memory, nonverbal problem-solving and visuospatial functions. A 68-year-old man visited our clinic for progressive speech disturbance since 1997. His main speech problems were word finding difficulty and loss of word meaning for objects. Language assessment demonstrated profound semantic memory loss for words with preserved fluency, corresponding to anomic aphasia. There were marked impairments in verbal and visual memory functions and word fluency tasks, but no grammatical or phonologic errors in speech. Also were there remarkable anosognosia and object visual agnosia with preserved visuospatial function and calculation in neuropsychological tests. Serial follow-up study of language test showed more deterioration in comprehension and repetition, consistent with Wernicke’s aphasia. Initial brain MR imaging and brain perfusion SPECT showed prominent focal atrophy in the left temporal lobe, and marked hypoperfusion in the left temporal and both frontal areas. Follow-up brain MR imaging and perfusion SPECT revealed more atrophy in both temporal lobes and showed more extensive hypoperfusion areas compared to the previous study.
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KEYWORD
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Frontotemporal lobar degeneration, Semantic dementia, Neuropsychological test, MRI, SPECT
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